| 1 |  Julian Baker Baker Brothers Advisors LP | | 1,992,783 | $124.95M | HOLD |
| 2 |  Jim Simons (Estate) Renaissance Technologies LLC | | 1,036,495 | $64.99M | HOLD |
| 3 |  David E. Shaw D.E. Shaw & Co LP | | 1,183,838 | $74.23M | HOLD |
| 4 |  Ray Dalio Bridgewater Associates LP | | 95,552 | $5.99M | HOLD |
| 5 |  Fidelity (FMR) Fidelity Management & Research | | 7,266,652 | $455.62M | HOLD |
| 6 |  Ken Fisher Fisher Asset Management LLC | | 1,113,568 | $69.82M | HOLD |
| 7 |  | | 18,161,519 | $1.14B | HOLD |
| 8 |  Dmitry Balyasny Balyasny Asset Management LP | | 206,412 | $12.94M | HOLD |
| 9 |  State Street State Street Global Advisors | | 6,496,130 | $407.31M | HOLD |
| 10 |  Goldman Sachs Goldman Sachs Asset Management | | 1,739,923 | $109.09M | HOLD |
| 11 |  T. Rowe Price T. Rowe Price Associates | | 1,043,732 | $65.44M | HOLD |
| 12 |  Joel Greenblatt Gotham Asset Management LLC | | 38,168 | $2.39M | HOLD |
| 13 |  Cliff Asness AQR Capital Management LLC | | 167,210 | $10.33M | HOLD |
| 14 |  Steve Cohen Point72 Asset Management LP | | 34,900 | $2.19M | HOLD |
| 15 |  JPMorgan Chase JPMorgan Asset Management | | 683,068 | $39.38M | HOLD |
| 16 |  Ken Griffin Citadel Advisors LLC | | 187,000 | $11.72M | HOLD |
| 17 |  Two Sigma Two Sigma Investments LP | | 35,800 | $2.24M | HOLD |
| 18 |  Paul Tudor Jones Tudor Investment Corp | | 6,500 | $407,550 | HOLD |
ARWR